A short summary of the database content of MACPAK Release 230.24009.

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Top 20 Entities in all models

Rank Entity name Type Number
1 NF-kappaB   143
2 LPS   132
3 MyD88   121
4 TLR4   117
5 TRAF6   110
6 TNF-alpha   101
7 TLR9   100
8 TNF-alpha   96
9 dsRNA   94
10 TRIF   91
11 TLR3   89
12 IRF-3   88
13 NF-kappaB{active}   85
14 IFN-beta   82
15 TLR2   71
16 IL-6   70
17 TLR7   68
18 p38   67
19 dsRNA:TLR3   67
20 IRF-7   66

Entity Types

Type Name Image Amount
Cell 52
Complex 5926
Dna 239
EntityBiological 89
EntityBiologicalCompartment 5354
EntityBiologicalEnvironment 1
ObjectUnknown 9
Protein 9849
Rna 76
RnaOther 14
SmallMolecule 756
mRNA 1643
miRNA 1

Total
24009

Literatures

Year Total
2008 - 2010 48
2005 - 2007 106
2002 - 2004 46
1999 - 2001 14
1996 - 1998 8
1993 - 1995 3
1990 - 1992 5
Total 230

Journals

Journal Papers
Virology. 1
Vaccine. 1
Trends Mol Med. 4
Trends Microbiol. 2
Trends Immunol. 16
Trends Cell Biol. 1
Trends Biotechnol. 1
Trends Biochem Sci. 1
Toxicology. 1
Semin Immunol. 5
Sci Signal. 1
Scand J Infect Dis. 1
Scand J Immunol. 1
Res Immunol. 2
Prostaglandins Other Lipid Mediat. 1
Proc Am Thorac Soc. 1
Pharmacol Ther. 3
Pathol Int. 1
Neurochem Int. 1
Nature. 1
Nat Rev Microbiol. 1
Nat Rev Immunol. 1
Nat Rev Drug Discov. 1
Nat Immunol. 1
Mol Reprod Dev. 1
Mol Med. 1
Mol Immunol. 3
Mol Cell. 1
Mol Cell Endocrinol. 1
Microbiol Immunol. 1
Microbes Infect. 5
Lab Invest. 1
J Pediatr. 1
J Pathol. 1
J Nutr. 1
J Mol Med. 1
J Leukoc Biol. 19
J Immunol. 3
J Gastroenterol Hepatol. 1
J Exp Med. 1
J Endocrinol. 1
J Cereb Blood Flow Metab. 1
J Cell Mol Med. 1
J Biol Chem. 12
J Autoimmun. 1
Int J Biochem Cell Biol. 5
Int Immunopharmacol. 1
Inflamm Res. 2
Immunopharmacology. 1
Immunology. 1
Immunol Rev. 5
Immunol Lett. 5
Immunol Cell Biol. 3
Immunogenetics. 1
Immunobiology. 8
Immunity. 8
IUBMB Life. 1
Free Radic Res. 1
Free Radic Biol Med. 2
Folia Biol (Praha). 1
FEBS Lett. 2
FASEB J. 1
Exp Mol Med. 1
Eur J Immunol. 1
EMBO Rep. 1
Cytokine. 5
Cytokine Growth Factor Rev. 5
Curr Opin Pharmacol. 1
Curr Opin Microbiol. 1
Curr Opin Immunol. 11
Curr Opin Genet Dev. 1
Curr Opin Cell Biol. 1
Curr Biol. 1
Clin Exp Immunol. 3
Cell. 1
Cell Signal. 2
Cell Res. 1
Cell Mol Life Sci. 2
Cell Mol Immunol. 3
Cell Microbiol. 1
Cell Host Microbe. 1
Cell Death Differ. 1
Brain Behav Immun. 1
Biomaterials. 1
Biol Res. 1
Biol Pharm Bull. 1
Biol Chem. 1
Biochimie. 2
Biochem Soc Trans. 5
Biochem Pharmacol. 5
Biochem J. 1
Autoimmun Rev. 1
Arterioscler Thromb Vasc Biol. 1
Annu Rev Biochem. 1
Ann Rheum Dis. 1
Ann N Y Acad Sci. 3
Adv Drug Deliv Rev. 5
Total 230

Journals (Tagcloud)

Adv Drug Deliv Rev.5 Ann N Y Acad Sci.3 Ann Rheum Dis.1 Annu Rev Biochem.1 Arterioscler Thromb Vasc Biol.1 Autoimmun Rev.1 Biochem J.1 Biochem Pharmacol.5 Biochem Soc Trans.5 Biochimie.2 Biol Chem.1 Biol Pharm Bull.1 Biol Res.1 Biomaterials.1 Brain Behav Immun.1 Cell Death Differ.1 Cell Host Microbe.1 Cell Microbiol.1 Cell Mol Immunol.3 Cell Mol Life Sci.2 Cell Res.1 Cell Signal.2 Cell.1 Clin Exp Immunol.3 Curr Biol.1 Curr Opin Cell Biol.1 Curr Opin Genet Dev.1 Curr Opin Immunol.11 Curr Opin Microbiol.1 Curr Opin Pharmacol.1 Cytokine Growth Factor Rev.5 Cytokine.5 EMBO Rep.1 Eur J Immunol.1 Exp Mol Med.1 FASEB J.1 FEBS Lett.2 Folia Biol (Praha).1 Free Radic Biol Med.2 Free Radic Res.1 IUBMB Life.1 Immunity.8 Immunobiology.8 Immunogenetics.1 Immunol Cell Biol.3 Immunol Lett.5 Immunol Rev.5 Immunology.1 Immunopharmacology.1 Inflamm Res.2 Int Immunopharmacol.1 Int J Biochem Cell Biol.5 J Autoimmun.1 J Biol Chem.12 J Cell Mol Med.1 J Cereb Blood Flow Metab.1 J Endocrinol.1 J Exp Med.1 J Gastroenterol Hepatol.1 J Immunol.3 J Leukoc Biol.19 J Mol Med.1 J Nutr.1 J Pathol.1 J Pediatr.1 Lab Invest.1 Microbes Infect.5 Microbiol Immunol.1 Mol Cell Endocrinol.1 Mol Cell.1 Mol Immunol.3 Mol Med.1 Mol Reprod Dev.1 Nat Immunol.1 Nat Rev Drug Discov.1 Nat Rev Immunol.1 Nat Rev Microbiol.1 Nature.1 Neurochem Int.1 Pathol Int.1 Pharmacol Ther.3 Proc Am Thorac Soc.1 Prostaglandins Other Lipid Mediat.1 Res Immunol.2 Scand J Immunol.1 Scand J Infect Dis.1 Sci Signal.1 Semin Immunol.5 Toxicology.1 Trends Biochem Sci.1 Trends Biotechnol.1 Trends Cell Biol.1 Trends Immunol.16 Trends Microbiol.2 Trends Mol Med.4 Vaccine.1 Virology.1

Process type

Process Type Count
ME_Binding 4778
ME_UnknownActivation 2137
ME_GeneExpression 1884
ME_Translation 1086
ME_Phosphorylation 1058
ME_Translocation 376
ME_Ubiquitination 225
ME_UnknownProduction 177
ME_ProteasomeDegradation 116
ME_Dimerization 110
ME_DNABinding 102
ME_Dissociation 97
ME_UnknownDegradation 97
ME_Cleavage 74
ME_MetabolicReaction 51
ME_Transcription 37
ME_ProteinCleavage 35
ME_Oxidation 33
ME_Deubiquitination 28
CE_CellDifferentiation 27
ME_Oligomerization 26
ME_Internalization 23
ME_Autophosphorylation 22
ME_Dephosphorylation 21
ME_Acetylation 19
ME_ChangeInMaterialConcentration 16
ME_Processing 13
ME_Hydrolysis 12
ME_Polymerization 9
ME_GDP-GTPExchange 9
ME_NuclearExport 8
ME_UnknownInactivation 8
ME_Sumoylation 7
CE_DNAReplication 6
ME_IonTransportThroughIonChannel 5
ME_Myristoylation 4
ME_CytosolicCalciumIonConcentrationElevation 3
ME_Colocalization 3
ME_UnknownInteraction 3
ME_Transference 3
CE_Cell-CellSignaling 2
ME_ChannelOpening_ClosingInThePlasmaMembrane 2
ME_ADPRibosylation 2
ME_Autocleavage 2
ME_Nitrosylation 2
ME_UnknownProcess 2
ME_Glycosylation 2
ME_Isomerization 2
ME_DNADamage 1
ME_MRNACleavage 1
ME_CAMPConcentrationElevation 1
ME_N-Glycosylation 1
ME_Reduction 1
ME_Methylation 1
CE_CellProliferation 1
- 1
ME_Trimerization 1
ME_O-Glycosylation 1
Total 12774

Entity location

Location of Entities Count
CellComponent 7091
Cytosol 5552
PlasmaMembrane_IntegralToPlasmaMembrane_ 2163
Nucleoplasm 1647
Extracellular 1498
Cytoplasm 805
PlasmaMembrane_InternalSideOfPlasmaMembrane_ 385
PlasmaMembrane_ExternalSideOfPlasmaMembrane_ 349
Cell_WithoutCellWall_ 313
Nucleolus 288
Cell 280
EndosomeLumen 279
PlasmaMembrane 258
NuclearChromosome 250
NuclearBody 243
NuclearEnvelopeLumen 243
NuclearOuterMembrane 242
NuclearLumen 240
NuclearPore 240
NuclearCentromere 239
Nucleus 238
NuclearEnvelope 238
Chromatin 238
NuclearInnerMembrane 238
EndosomeMembrane 151
Endosome 72
EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_ 22
EndoplasmicReticulum_IntegralToMembrane_ 19
EndoplasmicReticulum_Membrane_ 18
EndoplasmicReticulumLumen 18
EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_ 17
MitochondrialIntermembraneSpace 16
EndoplasmicReticulum 16
MitochondrialMatrix 12
MitochondrialLumen 10
MitochondrialOuterMembrane 10
Mitochondria 10
MitochondrialInnerMembrane 10
MitochondrialChromosome 10
MitochondrialEnvelope 10
MitochondrialCentromere 10
GolgiApparatus 6
GolgiTransFace 3
GolgiLumen 3
GolgiMembrane 3
Lysosome 2
LysosomalLumen 2
LysosomalMembrane 2
Total 24009